2008-2009 Basic and Clinical Science Course: Section 9: by Ramana S. Moorthy, MD

By Ramana S. Moorthy, MD

A dialogue of the scientific method of uveitis results in widely rewritten chapters on noninfectious (autoimmune) and infectious different types of uveitis. additionally coated are endophthalmitis, masquerade syndromes, and issues of uveitis. A dialogue on ocular involvement in AIDS has been up-to-date. The part on immunology describes the human immune reaction in phrases that make it hugely obtainable to readers.

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Additional resources for 2008-2009 Basic and Clinical Science Course: Section 9: Intraocular Inflammation and Uveitis (Basic and Clinical Science Course 2008-2009)

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Intraocular Inflammation and Uveitis NEURAL REFLEX ARC c=) Stimulus (stretch or pain) Sensory receptor i) AFFERENT PROCESSING Processing in CNS EFFECTOR Effector response ~(musclecontraction) IMMUNERESPONSE ARC c=) Stimulus (antigen) AFFERENT Antigen receptor i) PROCESSING EFFECTOR Processing in lymph node Effector response ~(immune Figure 2-' Comparison between effectors) the neural reflex arc and the immune response arc. CHAPTER 2: Immunization and Adaptive Immunity. 19 B lymphocytes, and T lymphocytes) into efferent lymphatics and venous circulation.

Any cell that is induced to express class II MHC molecules also can potentially serve as an APC, although this topic is beyond the scope of this discussion. In general, class II-dependent APCs are the most efficient, "professional" APCs for processing extracellular protein antigens that have been endocytosed from the external environment (eg, bacterial or fungal antigens). 1 HLA class II molecule 2 Peptide fragment 4 3 Activated T Lymphocyte T Lymphocyte Figure 2-2 Class II-dependent antigen-processing cells (APCs).

The subset of effector lymphocytes now grouped as non-T, non-B lymphocytes includes natural killer cells, lymphokine-activated cells, and killer cells. Antibodies, or immunoglobulins, are soluble antigen-specific effector molecules of adaptive immunity. After appropriate antigenic stimulation with T-lymphocyte help, B lymphocytes secrete IgM antibodies, and later other isotypes, into the efferent lymph fluid draining into the venous circulation. Antibodies then mediate a variety of immune effector activities by combining with antigen in the blood or in tissues.

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