Advanced Drug Formulation Design to Optimize Therapeutic by Robert O. Williams, David R. Taft, Jason T. McConville

By Robert O. Williams, David R. Taft, Jason T. McConville

Textual content discusses nanoparticle platforms for melanoma remedies, and likewise offers leading edge immono-regulation brokers for transplantation and the neighborhood concentrating on of gear, in particular poorly water soluble medications to supply better healing results. additionally, this name highlights components of treatment displaying the main promise for development in scientific results through complex formula layout.

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Furthermore, the formulation may be chemically less stable (and require stabilizers to reduce degradation) or may be more prone to temperature cycle instabilities and precipitation. Apart from the improvement in physical stability and metering consistency, a key advantage of using solution pMDI technology is the potential to accurately control the particle size distribution of the resulting aerosol. For suspension based systems, the aerosol particle size will ultimately be governed by the drug particulate size and adhesive/cohesive interactions.

Recent Advances in pMDI Technology Although the respiratory tract has been a therapeutic target for many centuries, the pMDI is generally considered the first generation of marketed inhalation products that adhere to the vigorous regulatory requirements. Marketed since their introduction by Riker Laboratories, Santa Barbara (now 3M Healthcare) (86) in 1956 and many authors have described their basic form and functionality (87,88). Fundamentally, pMDIs rely on aerosol propellant technology, in which a high vapor pressure gas (typically a liquid propellant) is contained in a pressurized canister, in a super-cooled state.

A simplistic representation of the ranges of surface geometries which may be encountered is shown in Figure 5. In simple terms, by varying the rugosity of a carrier it becomes possible to vary the degree of adhesion and, thus, alter the efficiency of drug liberation (Fig. 5). Although roughness is believed to be one of the dominating factors for the performance of such systems, it is generally very difficult to investigate the relationships between one material factor, in this case roughness, and performance without altering another potentially influencing factor, such as particle shape or quantity of intrinsic carrier fines.

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