Advances in Immunology, Vol. 55 by Frank J. Dixon

By Frank J. Dixon

From the reports of prior Volumes "Provides unrivalled worth in either educational and monetary phrases and may be bought by means of demanding pressed librarians as an immense precedence to be jealously defended." -JOURNAL OF clinical MICROBIOLOGY "Advances in Immunology needs to locate itself one of the such a lot energetic volumes within the libraries of our universities and institutions." -SCIENCE "A provocative and scholarly overview of research." -JOURNAL OF the yank clinical organization "Deserves an enduring position in biomedical libraries as an relief in learn and in teaching." -JOURNAL OF IMMUNOLOGIC equipment

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Advances in Immunology, Vol. 55

From the reports of earlier Volumes "Provides unrivalled worth in either educational and monetary phrases and will be bought through demanding pressed librarians as an enormous precedence to be jealously defended. " -JOURNAL OF clinical MICROBIOLOGY "Advances in Immunology needs to locate itself one of the such a lot energetic volumes within the libraries of our universities and associations.

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STEM CELL FACTOR 37 VIII. Biological Consequences of Interactions between the SCF Receptor and Its Ligand A. ADHESION The membrane-associated form of SCF can mediate the adhesion of cells that express the SCFR. This point was first established by Flanagan et aZ. (1991), who demonstrated that in vitro-derived mouse mast cells adhered to COS cells that had been transfected with the membrane-associated (wild type) but not the soluble (SZd) form of SCF. SubsequentIy, Kaneko et aZ. (1991) and Adachi et aZ.

IX. Lymphohematopoiesis A. HEMATOPOIESIS In broad outline, hematopoiesis is characterized by the sustained self-renewal of a population of hematopoietic stem cells and by the regulated differentiation from this stem cell pool of various lineages with specialized function, such as red cells, megakaryocytes, granulocytes, monocytes, and mast cells. Many of the most differentiated products of hematopoiesis, such as red cells, platelets, and mature 44 STEPHEN J . GALL1 ET AL. granulocytes, have both a relatively short half-life and no proliferative ability.

These findings indicate that SCF can promote mouse or rat mast cell differentiation in uitro. , 1992). , 1991b). These findings may indicate that factors in addition to SCF are required for full mast cell maturation. Moreover, certain effects of SCF on mouse mast cell phenotype apparently can be antagonized by other cytokines. , 1992). Taken together, these findings indicate that SCF can promote mast cell differentiation/maturation, but that the phenotypic characteristics of this cell type are regulated by a complex interplay of SCF and other cytokines.

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