Antibody Engineering, Methods and Protocols by Benny K. C. Lo

By Benny K. C. Lo

This publication offers state of the art ideas in antibody engineering. partially 1, renowned assets for antibody series research are defined, including in-depth discussions on antibody structural modeling.

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P. (1999) The IMGT unique numbering for Immunoglobulins, T cell receptors and Ig-like domains. The Immunologist 7, 132–136. 34. Kabat, E. , Wu, T. , Perry, H. , Gottesman, K. , and Foeller, C. (1991) Sequences of proteins of immunological interest. , pp. 91–3242. 35. , Cohen, G. , Padlan, E. , and Davies, D. R. (1986) Phosphocholine binding immunoglobulin Fab McPC603. J. Mol. Biol. 190: 593–604. 36. Chothia, C. and Lesk, A. M. (1987) Canonical structures for the hypervariable regions of immunoglobulins.

Fr). Exceptionally, the IMGT/V-QUEST reference directory sets may include sequences isolated from pseudogene allele IMGT reference sequences [indicated with (P) following the allele name]. For sequence alignments, the IMGT/V-QUEST uses the DNAPLOT program, an alignment tool that is part of IMGT, developed by Hans-Helmar Althaus and Werner Müller (Institut für Genetik, Köln, Germany). Since 1997, the IMGT/VQUEST developments have been implemented by Véronique Giudicelli (IMGT, LIGM, Université Montpellier II, Montpellier, France).

Other data comprise: i) phages; ii) probes used for the analysis of IG and TR gene rearrangements and expression, and restriction fragment-length polymorphism (RFLP) studies; iii) data related to gene regulation and expression: promoters, IMGT 35 primers, cDNAs, and reagent monoclonal antibodies (MAbs); iv) genes and clinical entities: translocations and inversions, humanized antibodies, MAbs with clinical indications; v) taxonomy of vertebrate species present in IMGT/LIGM-DB; vi) immunoglobulin superfamily: gene exon–intron organization, protein displays, Colliers de Perles, and 3D representations of V-LIKE and C-LIKE domains.

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