By Benny K. C. Lo
This publication offers state of the art ideas in antibody engineering. partially 1, renowned assets for antibody series research are defined, including in-depth discussions on antibody structural modeling.
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Extra info for Antibody Engineering, Methods and Protocols
P. (1999) The IMGT unique numbering for Immunoglobulins, T cell receptors and Ig-like domains. The Immunologist 7, 132–136. 34. Kabat, E. , Wu, T. , Perry, H. , Gottesman, K. , and Foeller, C. (1991) Sequences of proteins of immunological interest. , pp. 91–3242. 35. , Cohen, G. , Padlan, E. , and Davies, D. R. (1986) Phosphocholine binding immunoglobulin Fab McPC603. J. Mol. Biol. 190: 593–604. 36. Chothia, C. and Lesk, A. M. (1987) Canonical structures for the hypervariable regions of immunoglobulins.
Fr). Exceptionally, the IMGT/V-QUEST reference directory sets may include sequences isolated from pseudogene allele IMGT reference sequences [indicated with (P) following the allele name]. For sequence alignments, the IMGT/V-QUEST uses the DNAPLOT program, an alignment tool that is part of IMGT, developed by Hans-Helmar Althaus and Werner Müller (Institut für Genetik, Köln, Germany). Since 1997, the IMGT/VQUEST developments have been implemented by Véronique Giudicelli (IMGT, LIGM, Université Montpellier II, Montpellier, France).
Other data comprise: i) phages; ii) probes used for the analysis of IG and TR gene rearrangements and expression, and restriction fragment-length polymorphism (RFLP) studies; iii) data related to gene regulation and expression: promoters, IMGT 35 primers, cDNAs, and reagent monoclonal antibodies (MAbs); iv) genes and clinical entities: translocations and inversions, humanized antibodies, MAbs with clinical indications; v) taxonomy of vertebrate species present in IMGT/LIGM-DB; vi) immunoglobulin superfamily: gene exon–intron organization, protein displays, Colliers de Perles, and 3D representations of V-LIKE and C-LIKE domains.