Cytokines in Human Health: Immunotoxicology, Pathology, and by Robert V. House, Jacques Descotes

By Robert V. House, Jacques Descotes

This complete publication explores the function of cytokines in immunotoxicology and human well-being utilizing a number of complicated equipment, from uncomplicated examine to hugely utilized healing functions. It contains a uncomplicated research of cytokines and info the results of cytokines at the immune approach and in treating melanoma. The booklet serves as either a primer and a place to begin for a extra certain research of the position those organic regulators play.

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Additional info for Cytokines in Human Health: Immunotoxicology, Pathology, and Therapeutic Applications (METHODS IN PHARMACOLOGY AND TOXICOLOGY)

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2. Intracellular Cytokine Staining A major advantage of intracellular cytokine staining over the ELISPOT assay is the ability to analyze multiple parameters per cell (21). Such data can be very valuable to gain insight into immune response regulation and memory formation. This technique can also be used on whole blood without requiring separation of PBMCs; a protocol is as follows. Heparinized blood samples are stimulated with antigen plus CD28 and CD49d in the presence of secretion inhibitor Brefeldin A for 6 h at 37°C.

17. Posadas S, Leyva L, Torres M, et al. Subjects with allergic reactions to drug show in vivo polarized patterns of cytokine expression depending on the chronology of the clinical reaction. J Allergy Clin Immunol 2000;106:769–776. 18. Gaspard I, Guinnepain MT, Laurent J, et al. IL-4 and IFN-γ mRNA Induction in peripheral lymphocytes specific for β-lactam antibiotics in immediate or delayed hypersensitivity reactions. J Clin immunol 2000;20:107–116. 19. Brugnolo F, Annunziato F, Sampognaro S, et al.

42. Kadowaki N, Ho S, Antonenko S, Malefyt RW, Kastelein RA, Bazan F, Liu YJ. Subsets of human dendritic cell precursors express different toll-like receptors and respond to different microbial antigens. J Exp Med 2001;194:863–869. 43. Parronchi P, De Carli M, Manetti R, et al. IL-4 and IFN (alpha and gamma) exert opposite regulatory effects on the development of cytolytic potential by Th1 or Th2 human T-cell clones. J Immunol 1992;149:2977–2983. 44. Schandene L, Del Prete GF, Cogan E, et al. Recombinant interferon-alpha selectively inhibits the production of interleukin-5 by human CD4+ T-cells.

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